PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology
Identifieur interne : 000E46 ( Main/Exploration ); précédent : 000E45; suivant : 000E47PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology
Auteurs : Julie L. Mcauley [États-Unis] ; Jerry E. Chipuk [États-Unis] ; Kelli L. Boyd [États-Unis] ; Nick Van De Velde [États-Unis] ; Douglas R. Green [États-Unis] ; Jonathan A. Mccullers [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2010.
Abstract
With the recent emergence of a novel pandemic strain, there is presently intense interest in understanding the molecular signatures of virulence of influenza viruses. PB1-F2 proteins from epidemiologically important influenza A virus strains were studied to determine their function and contribution to virulence. Using 27-mer peptides derived from the C-terminal sequence of PB1-F2 and chimeric viruses engineered on a common background, we demonstrated that induction of cell death through PB1-F2 is dependent upon BAK/BAX mediated cytochrome
Url:
DOI: 10.1371/journal.ppat.1001014
PubMed: 20661425
PubMed Central: 2908617
Affiliations:
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Mcauley</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chipuk, Jerry E" sort="Chipuk, Jerry E" uniqKey="Chipuk J" first="Jerry E." last="Chipuk">Jerry E. Chipuk</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. Boyd</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Pathology, Division of Comparative Medicine, Vanderbilt University, Nashville, Tennessee, United States of America.</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pathology, Division of Comparative Medicine, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Van De Velde, Nick" sort="Van De Velde, Nick" uniqKey="Van De Velde N" first="Nick" last="Van De Velde">Nick Van De Velde</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R." last="Green">Douglas R. Green</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>With the recent emergence of a novel pandemic strain, there is presently intense interest in understanding the molecular signatures of virulence of influenza viruses. PB1-F2 proteins from epidemiologically important influenza A virus strains were studied to determine their function and contribution to virulence. Using 27-mer peptides derived from the C-terminal sequence of PB1-F2 and chimeric viruses engineered on a common background, we demonstrated that induction of cell death through PB1-F2 is dependent upon BAK/BAX mediated cytochrome <italic>c</italic> release from mitochondria. This function was specific for the PB1-F2 protein of A/Puerto Rico/8/34 and was not seen using PB1-F2 peptides derived from past pandemic strains. However, PB1-F2 proteins from the three pandemic strains of the 20<sup>th</sup> century and a highly pathogenic strain of the H5N1 subtype were shown to enhance the lung inflammatory response resulting in increased pathology. Recently circulating seasonal influenza A strains were not capable of this pro-inflammatory function, having lost the PB1-F2 protein's immunostimulatory activity through truncation or mutation during adaptation in humans. These data suggest that the PB1-F2 protein contributes to the virulence of pandemic strains when the PB1 gene segment is recently derived from the avian reservoir.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name></author><author><name sortKey="De La Rosa Zamboni" uniqKey="De La Rosa Zamboni">de la Rosa-Zamboni</name></author><author><name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce de Leon</name></author><author><name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name></author><author><name sortKey="Quinones Falconi, F" uniqKey="Quinones Falconi F">F Quinones-Falconi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L 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sortKey="Krauss, S" uniqKey="Krauss S">S Krauss</name></author><author><name sortKey="Perez, D" uniqKey="Perez D">D Perez</name></author><author><name sortKey="Webby, R" uniqKey="Webby R">R Webby</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vigerust, Dj" uniqKey="Vigerust D">DJ Vigerust</name></author><author><name sortKey="Ulett, Kb" uniqKey="Ulett K">KB Ulett</name></author><author><name sortKey="Boyd, Kl" uniqKey="Boyd K">KL Boyd</name></author><author><name sortKey="Madsen, J" uniqKey="Madsen J">J Madsen</name></author><author><name sortKey="Hawgood, S" uniqKey="Hawgood S">S Hawgood</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Mcauley, Julie L" sort="Mcauley, Julie L" uniqKey="Mcauley J" first="Julie L." last="Mcauley">Julie L. Mcauley</name></region><name sortKey="Boyd, Kelli L" sort="Boyd, Kelli L" uniqKey="Boyd K" first="Kelli L." last="Boyd">Kelli L. Boyd</name><name sortKey="Chipuk, Jerry E" sort="Chipuk, Jerry E" uniqKey="Chipuk J" first="Jerry E." last="Chipuk">Jerry E. Chipuk</name><name sortKey="Green, Douglas R" sort="Green, Douglas R" uniqKey="Green D" first="Douglas R." last="Green">Douglas R. Green</name><name sortKey="Mccullers, Jonathan A" sort="Mccullers, Jonathan A" uniqKey="Mccullers J" first="Jonathan A." last="Mccullers">Jonathan A. Mccullers</name><name sortKey="Van De Velde, Nick" sort="Van De Velde, Nick" uniqKey="Van De Velde N" first="Nick" last="Van De Velde">Nick Van De Velde</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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